177 research outputs found

    Second Reaction: On the Way Home

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    New and Transformed Places: Representations of Home in Books for Children and Adolescents

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    Teacher that Jack built: The construction of teacher subjects in an early field experience course

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    Scope and Method of Study: Increased standardization of teacher education program urges a reconsideration of how pre-service teacher identities are constructed/being constructed. The purpose of my study was to examine the writings of preservice teachers enrolled in an early field experiences course in order to identify moments in which they interacted with, negotiated, and subverted the teacher-making process, which they officially enter during the semester they take this course.Findings and Conclusions: An analysis of pre-service teachers enrolled in an early field experience course using Julia Kristeva's theory of the subject-in trial illustrates how their language disrupts, contradicts, and reappropriates the standardized language of teacher candidate programs. Examining the writings of pre-service teachers through this theoretical framework illustrates how some of them are not only subjects-in-the-making but they are also remaking the system they are entering

    Ceramic foam substrates for automotive catalyst applications: fluid mechanic analysis

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    Several properties of ceramic foams render them promising substrates for various industrial processes. For automotive applications, the foam properties that need to be further studied include the substrate impact on the exhaust gas flow, in terms of pressure drop and flow uniformity. In this paper, pressure drop measurements are performed with different honeycomb and ceramic foam substrates, and pressure drop correlations are discussed. The flow uniformity upstream and downstream of the substrates is evaluated using particle image velocimetry. The results show that ceramic foam substrates induce higher pressure drop, while increasing the uniformity of the flow. In contrast to honeycomb monoliths, the flow uniformity downstream of ceramic foams does not decrease with increasing flow velocity. The higher flow uniformity of ceramic foams is not only caused by their higher pressure drop, but also by flow homogenization that occurs inside the ceramic foam structure, as a result of the momentum exchange perpendicular to the main flow directio

    Buffy, Ballads, and Bad Guys Who Sing: Music in the Worlds of Joss Whedon

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    Edited Collection of essays on music in Buffy the Vampire Slayer, Angel, Firefly, and Dr. Horrible's Sing-Along Blo

    Synthesizing the connections between environmental disturbances and zoonotic spillover

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    Zoonotic spillover is a phenomenon characterized by the transfer of pathogens between different animal species. Most human emerging infectious diseases originate from non-human animals, and human-related environmental disturbances are the driving forces of the emergence of new human pathogens. Synthesizing the sequence of basic events involved in the emergence of new human pathogens is important for guiding the understanding, identifi cation, and description of key aspects of human activities that can be changed to prevent new outbreaks, epidemics, and pandemics. This review synthesizes the connections between environmental disturbances and increased risk of spillover events based on the One Health perspective. Anthropogenic disturbances in the environment (e.g., deforestation, habitat fragmentation, biodiversity loss, wildlife exploitation) lead to changes in ecological niches, reduction of the dilution effect, increased contact between humans and other animals, changes in the incidence and load of pathogens in animal populations, and alterations in the abiotic factors of landscapes. These phenomena can increase the risk of spillover events and, potentially, facilitate new infectious disease outbreaks. Using Brazil as a study model, this review brings a discussion concerning anthropogenic activities in the Amazon region and their potential impacts on spillover risk and spread of emerging diseases in this region

    Congenital Hydrocephalus and Abnormal Subcommissural Organ Development in Sox3 Transgenic Mice

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    Congenital hydrocephalus (CH) is a life-threatening medical condition in which excessive accumulation of CSF leads to ventricular expansion and increased intracranial pressure. Stenosis (blockage) of the Sylvian aqueduct (Aq; the narrow passageway that connects the third and fourth ventricles) is a common form of CH in humans, although the genetic basis of this condition is unknown. Mouse models of CH indicate that Aq stenosis is associated with abnormal development of the subcommmissural organ (SCO) a small secretory organ located at the dorsal midline of the caudal diencephalon. Glycoproteins secreted by the SCO generate Reissner's fibre (RF), a thread-like structure that descends into the Aq and is thought to maintain its patency. However, despite the importance of SCO function in CSF homeostasis, the genetic program that controls SCO development is poorly understood. Here, we show that the X-linked transcription factor SOX3 is expressed in the murine SCO throughout its development and in the mature organ. Importantly, overexpression of Sox3 in the dorsal diencephalic midline of transgenic mice induces CH via a dose-dependent mechanism. Histological, gene expression and cellular proliferation studies indicate that Sox3 overexpression disrupts the development of the SCO primordium through inhibition of diencephalic roof plate identity without inducing programmed cell death. This study provides further evidence that SCO function is essential for the prevention of hydrocephalus and indicates that overexpression of Sox3 in the dorsal midline alters progenitor cell differentiation in a dose-dependent manner
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